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Osteosarcoma of jaw slideshare

Osteosarcoma 1. Presented by: SANA ARMAN 2. • OSTEO = Bone • SARCOMA = Malignant tumour of connective tissue 3. OVERVIEWOVERVIEW • Introduction • Epidemiology • Classification • Skeletal Distribution • Etiology • Clinical and Radiographic features • Histopathology • Staging • Treatment and Prognosi Osteosarcoma• The commonest primary malignant tumor of the bone but is relatively rare in the jaw. Characterized by direct formation of bone or osteoid by tumor cells (WHO) Unknown cause 16. Osteosarcoma• The tumor may follow pre- existing jaw bone condition:1. Radiation of head and neck .2. Paget's disease .3. Fibrous dysplasia .4

Osteosarcoma

slide 90 of 92. Comments: Osteosarcomas of the jawbones are different from the conventional osteosarcomas in several aspects. They tend to occur in slightly older individuals than conventional osteosarcomas - patients are in 2nd to 4th decades of life. Pain and swelling are the presenting symptoms Osteosarcoma is the most common primary malignant bone tumor, and in the jaws represents up to 23% of total head and neck malignancies [1,2]. Osteosarcomas of the jaws are, however, rare lesions, representing only 2 to 10% of all osteosarcomas [3-5]. Ten percent of these lesions are radiation induced Osteosarcoma of the jaw is a rapidly invasive lesion, there RADIOGRAPHIC FEATURES The radiographic features of osteosarcoma are variable depending on the degree of bone formation in the tumor. In the osteoblastic or sclerosing type irregular foci of radiopacity intermingled with areas of radiolucency is noted

Osteosarcoma of Jaw Bones High Quality Pathology Images of Orthopedic, Bone Tumors - I, Osteosarcoma Osteosarcoma (OS) accounts for about 20% of all sarcomas with gnathic involvement seen in about 6%-10% of all OSs. The clinical presentation of OSs in the jaws is different from that of long bones as swelling is the most common complaint in patients with jaw OS followed by pain. The histopathologic variables seen are more favorable in OSs of jaws reported that osteosarcoma of the jaw constituted 0.6% of lesions of the jaws and oral cavity over a 21-year period in a Nigerian institution; the patients' mean age was 27 years. While mandibular lesions occurred predominantly in women, their study suggested a male predisposition of maxillary lesions [ 8 ] The surgical margin evaluation was tralesional surgery. All the patients had recurrences, and marginal in one area and wide in the rest of the surgical margin. No. 7 OSTEOSARCOMA OF THE JAW the local pathologists made the diagnosis of osteochon- droma in two patients Osteosarcoma of the jaw bone is comparatively rare and accounts for about 6.5% of all osteosarcomas. We treated eight cases of osteosarcoma of the jaw bone involving the mandible and maxilla in equal proportions between 1986-1992. The median age was 31 years and male: female ratio was 5:3

Osteosarcoma of the jaw (OSJ) is a rare malignancy, accounting for less than 1% of head and neck malignancies. OSJ can arise as a primary malignancy or secondary to locoregional radiation treatment. Radiologically, these tumors show large, destructive growth with periosteal reaction, which can suggest the diagnosis of osteosarcoma (OS) Osteosarcoma of the head and neck (OHN) is a rare presentation of osteosarcoma, with <10% of all cases of osteosarcoma presenting in this region. 1 OHN exhibits a clinical behavior and natural history that are distinct from those of osteosarcoma of the trunk and extremity. 1 Compared with the extremity/trunk presentation of this disease, OHN demonstrates less of a propensity to metastasize to pulmonary and other sites, but a high lethality associated with local disease that is difficult to. Older patients: jaw, pelvis, spine (Cancer 2009;115:1531) Multifocal osteosarcoma: may occur in the setting of Paget disease of the bone Very rare: small bones of hands and feet Parosteal osteosarcoma: arises on cortical surface, usually metaphysis Most common: distal posterior femur Other sites: proximal tibia, proximal humeru The prognosis of osteosarcoma of the jaws is better than that of long bone, with a 5-year-survival rate of 25.8 percent for the maxilla and 34.8 percent for the mandible. The median survival time for the maxilla is 2.9 years and 6.5 years for the mandible [ 21 Osteosarcoma of the Jaw/Craniofacial Region Outcomes After Multimodality Treatment B. Ashleigh Guadagnolo, MD, MPH 1; Gunar K. Zagars, MD ; A. Kevin Raymond, MD2; Robert S. Benjamin, MD3; and Erich M. Sturgis, MD, MPH4,5 BACKGROUND: The current study was performed to evaluate outcomes in patients with osteosarcoma of

Osteosarcoma (1)

Jaw bone disaese ii - SlideShar

Osteosarcoma of Jaw Bones - WebPatholog

Osteosarcomas can also develop in the skull (most commonly in the oral cavity), pelvis, ribs, and vertebrae. Cats with osteosarcoma of the jaw (a form of axial osteosarcoma) may have swelling of the jaw, difficulty opening the mouth, excessive salivation, and may be reluctant to eat due to pain.If an osteosarcoma develops elsewhere in the skull or vertebrae, swelling and pain in the head or. Thirty-eight patients presented with previously untreated, predominantly low-grade juxtacortical osteosarcoma. There were 12 (32%) men and 26 (68%) women with a mean age of 28.9 years. [miami.pure.elsevier.com] Bullough, MB, ChB, presents a unique, lavishly illustrated account of the pathology of arthritic disorders, metabolic disturbances, and soft tissue and bone tumors erature. Chindia et al. [11] reported on 14 cases of jaw osteosarcomas in patients with a mean age of 30 years (one week to 50 years). The mandible was the most com-monly involved bone, as in other studies [1,2,11]. Ogun-lewe et al. [8] reported that osteosarcoma of the jaw constituted 0.6% of lesions of the jaws and oral cavity ove Osteosarcoma treatment typically involves surgery and chemotherapy. Radiation therapy might be an option in certain situations. Surgery. The goal of surgery is to remove all of the cancer cells. But planning the operation also takes into consideration how it will affect your ability to go about your daily life. The extent of surgery for.

In a report by Janecka et al. , six (3.3%) of 183 patients who underwent cranial base surgery were found to have osteosarcoma. This number represents 5.1% of the 118 malignant tumors and 16% of the sarcomas. Primary intracerebral osteosarcoma (without bony or dural attachment) is rare (2- 4, 6- 8). Among those cases that have been reported. Eur J Cancer 2001; 37: 760- 766). Osteosarcoma is the most frequent primary cancer of bone (incidence ~ 0.2/100 000 per year). The incidence is higher in adolescents (0.8-1.1/100 000 per year at age 15 -19 ), where it accounts for >10% of all solid cancers. The male : female ratio is 1.4 : 1. 3. In children and adolescents, > 50% of these. Osteosarcoma of the jaw (JOS) is extremely rare, representing about 7% of all osteosarcomas and 1% of all head and neck malignancies [1, 2, 5-9]. The mandible and maxilla are almost equally involved. Unlike long-bone osteosarcoma, JOS is diagnosed more frequently in men than in females and presents about two decades later Osteosarcoma. and its Variants Amit M. Patel, MS William Simmons, PhD. Acknowledgements. Pictures in this Power-Point was graciously provided by Dr. S. R. Patel, a practicing oncologist working at Rush Presbyterian Hospital in Chicago, IL All information in these slides came from previous lecture notes on the subject at Texas A&M University and material from the Oxford Textbook of Patholog Osteosarcoma of the jaw - experience at the Medical University Vienna and comparative study with inter-national tumor registries Christina Eder-Czembirek,I Doris Moser,I Simone Holawe,I Thomas Brodowicz,II Jutta Ries,III Irene Sulzbacher,IV Edgar Selzer V,* IDepartment of Cranio, Maxillofacial and Oral Surgery, Medical University Vienna, Vienna, Austria. II Department of Internal Medicine I.

Osteosarcoma of the jaws: a review of literature and a

Osteosarcoma Bone Neoplasm

  1. e factors including treatment modalities which influence survival in patients with osteosarcoma of the head and neck. Study Design: Retrospective clinicopathologic study of 27 p..
  2. Tags: Jaw, Meg, osteosarcoma, Surgery. Apparently this type of low grade osteosarcoma is commonly misdiagnosed at Fibrous Dysplasia because on a pathology slide they have a similar appearance, but you need all the information (CT scan, background, X-ray) to make a definitive diagnosis of the low-grade osteosarcoma because it's very rare..
  3. Radiopaque jaw lesions are frequently encountered at radiography and computed tomography, but they are usually underevaluated or underdescribed in radiology reports. A systematic approach to the evaluation of radiopaque jaw lesions is necessary to diagnose the lesion or at least provide a meaningful differential diagnosis
  4. Results. Tumors of the flat bone comprised 91 (11.3%) of 806 osteosarcoma cases. Eight cases were secondary osteosarcoma associated with previous radiotherapy. Patients with a flat bone tumor were significantly older and more likely to present with metastases at diagnosis than extremity tumor. The proportions of female sex and chondroblastic.

Because osteosarcoma is a deadly form of cancer, no absolute contraindications for treatment exist. Relative contraindications would include situations in which the patient is so frail that the risks of general anesthesia outweigh any potential benefits of surgery. Another relative contraindication would be a situation in which the patient has extensive, overwhelming metastatic disease, and. Osteosarcoma is the most common primary cancer of bone and typically occurs during the adolescent growth spurt. The incidence of osteosarcoma is similar worldwide 1,2,3,4,5.Association studies.

Osteosarcoma of jaws: Challenges in diagnosi

Multilocular Radiolucencies Of Jaw PowerPoint PPT Presentations. 1. Solitary cystlike Radiolucencies not necessarily contacting teeth - Differential Diagnosis of Oral and Maxillofacial lesions 1. Solitary cystlike Radiolucencies not necessarily contacting teeth 2 Osteosarcoma (OS) is the most common malignant bone tumor and the majority of recurrences are due to metastasis. However, the molecular mechanisms that regulate OS metastatic spread are largely.

A sarcoma is a malignant mesenchymal tumour associated with varied clinical presentations and pathological classifications. In the craniofacial region rhabdomyosarcoma or osteosarcoma (OS) are most commonly seen [].OS makes up approximately 20% of all sarcomas and is the most common non-haematopoietic primary bone neoplasm, with a reported incidence of around 1 in 100,000 [] Aim: This study aimed to document the total number of osteosarcomas of bone diagnosed in a referral hospital differentiating from its close mimics with biologic behavior.Materials and Methods: This study analyzes the total cases diagnosed as osteosarcoma from 2014 to 2016 in the Department of Pathology, SCB Medical College, Cuttack, Odisha.Results: A total of 21 cases were diagnosed with. The benign bone lesions--osteoma, osteoid osteoma, and osteoblastoma--are characterized as bone-forming because tumor cells produce osteoid or mature bone. Osteoma is a slow-growing lesion most commonly seen in the paranasal sinuses and in the calvaria. When it occurs in the long bones, it is invari

The istituto rizzoli-beretta experience with osteosarcoma

Objective: To determine factors including treatment modalities which influence survival in patients with osteosarcoma of the head and neck. Study Design: Retrospective clinicopathologic study of 27 patients with osteosarcoma of the head and neck. Methods: The clinical charts and pathology slides were reviewed on 27 patients who had osteosarcoma of the head and neck between 1946 and 1998 osteosarcoma. Subsequent bone biopsy had been reported as an osteosarcoma NOS. Since it has been reported in the private sector it was not possible to retrieve the slides. The history demonstrates the variable clinical and radiological features of low grade central osteosarcoma which can mimic a benign lesion

Microscope slides of the biopsy and the surgical specimen were reviewed. Patients with osteosarcoma in the jaw bones or cranium, low grade and high grade surface variants, dedifferentiated chondrosarcoma, primary metastasis at presentation, and secondary osteosarcomas were discarded from our study 1. One of the most important signs of this disorder is deviation of the jaw on mouth opening and closing. 2. Complaint of mandibular movements. ( i.e. locking or dislocation) 3. Repeatable joint noises during mandibular opening and closing. 4. Radiographic findings may demonstrate bony changes or deviation in joint form (i.e Osteosarcoma is the second most common bone cancer. It occurs in two or three new people per million people each year. Most cases occur in teenagers. Most tumors occur around the knee. Other common locations include the hip and shoulder. Ewing's sarcoma most commonly occurs between age 5 and 20. The most common locations are the upper and lower.

Video: Osteosarcoma of the jaw bones - ScienceDirec

Osteosarcoma of the jaw: report of 3 cases (including the

To evaluate the activity and safety of the PD-1 antibody pembrolizumab in adult patients with advanced osteosarcoma. The study was a single-arm, open-label, phase 2 trial in patients with unresectable, relapsed osteosarcoma. The primary endpoint was clinical benefit rate (CBR) at 18 weeks of treatment, defined as complete response, partial response, or stable disease using RECIST v1.1 Check also: WHO histological classification of tumours of the oral cavity and mobile tongue. WHO histological classification of tumours of the oropharynx (base of tongue, tonsils, adenoids) Odontogenic carcinomas. Ameloblastic carcinoma. 9270/3. Primary intraosseous carcinoma, NOS. 9270/3. Sclerosing odontogenic carcinoma Case Report Atypical Presentation of a Maxillary Chondroblastic Osteosarcoma and Complex Management Jayan George 1,* , Mohamed Abdulla 2, Amir Farboud 2, Gareth Leopold 3 and Conor Marnane 2 1 General Surgical Department, Sheffield Teaching Hospitals NHS Foundation Trust, Herries Road, Sheffield S5 7AU, UK 2 ENT Head and Neck surgery department, Morrison Hospital, Swansea SA6 6NL, UK

Osteosarcoma most often occurs in the metaphysis of long bones, most commonly in the distal femur, followed by the proximal tibia and proximal humerus; less common sites of disease include the skull, pelvis, and jaw. 1 A 2007 report of 11,961 cases of osteosarcoma from the National Cancer Database reported by Damron, Ward, and Stewart showed. Osteosarcoma is a type of bone cancer that most often affects children and teens. Learn more about the subtypes, causes, symptoms, diagnosis, treatment, and prognosis for osteosarcoma the maxillofacial region.2-4 Osteosarcoma of the jaw commonly occurs in the third and fourth decade of life.4 There is scarce published information on osteogenic sarcoma of the jaw bones in Malaysia. This study records the clinicopathological features of jaw osteosarcomas diagnosed histologically in the Malaysian Ministry of Health's main ora Gnathic osteosarcoma is a subtype of osteosarcoma that primarily affects the mandible (horizontal ramus) and maxilla (alveolar ridge, sinus floor, and palate). Epidemiology represents ~6% of osteosarcomas 3 60% in males has an older onset (~..

Osteosarcoma of the jaw/craniofacial region - Guadagnolo

  1. of origin, with the majority of cysts in the jaw aris-ing from odontogenic sources (2). However, cysts may also arise from prior trauma or surgery. The wide range in the frequency with which various cystic lesions occur often helps narrow the differ-ential diagnosis (Table 4). Table 5 Prevalence of Solid Benign Mandibular Lesions Most common.
  2. Osteosarcoma is one of the most devastating cancers with associated poor prognosis. Chronic bone inflammation frequently predisposes to tumorigenesis and progression of osteosarcoma. In the tumor inflammatory microenvironment, caspase-1 and its processed cytokines such as interleukin 1β (IL-1β) play an important role in the occurrence and development of cancer. Berberine is an isoquinoline.
  3. {{configCtrl2.info.metaDescription}} This site uses cookies. By continuing to browse this site you are agreeing to our use of cookies
  4. ation of slides is required to detect direct formation of osteoid by malignant spindle cells, a feature that tilts the balance in favor of the latter entity.7 Additional helpful criterion is young age of the patient, which favors giant cell-rich osteosarcoma as chances of developing gian
  5. 'osteosarcoma in combination with head and neck locations, such as jaw, mandible, maxilla, larynx, or skull. Patients older than 16 years of age with a histo-pathological proven diagnosis of osteosarcoma and with a primary location in the head and neck region were included
  6. Osteosarcoma occurs most often in children and young adults between the ages of 10 and 20 and often during a growth spurt. It occurs more frequently in boys than girls. Osteosarcoma is a bone cancer, which means it can spread to other organs or tissues in the body, most commonly starting with the lungs

Pathology Outlines - Conventional osteosarcoma and

  1. static osteosarcoma,forwhom bothbiopsyand tumor resection specimens and clinicalfollow-upwereavail-able, were retrieved from the ® les of Mount Sinai Hospital. Low grade or surface osteosarcomas, oste-osarcomas of the jaw or soft tissue, and osteosar-comas arising in pre-existing bone disease such a
  2. Osteosarcomas are somewhat rare in cats and progress slowly. Osteosarcoma is very painful. The most common location where osteosarcomas develop in cats is the hindlimb. Amputation is by far the most common treatment. Chemotherapy is not generally pursued without evidence of metastasis, given the relatively long-term control with surgery alone
  3. Sunburst appearance periosteal reaction in a pathologically proven case of osteosarcoma . The sunburst appearance occurs when the lesion grows too fast. It is frequently associated with osteosarcoma but can also occur with Ewing sarcoma or osteoblastic metastases
  4. 30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA
  5. Ostesarcoma - Pathology, Histology Slides for the practical part of the pathology exam at Masaryk University http://atlases.muni.cz/atlases/stud/atl_en/main+..
  6. Osteosarcoma & Paget-disease-of-the-bone & Peripheral-neuropathy Symptom Checker: Possible causes include Paget Disease of the Bone. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search

Overview. On MRI, osteosarcoma is characterized by intermediate intensity of soft tissue and low signal intensity of ossified components on T1.High signal intensity of soft tissue and low signal intensity of ossified components on T2.Considerable contrast enhancement of solid components on T1 contrast.. MRI. MRI is proving essential in accurate local staging and assessment for limb sparing. What is osteosarcoma? Osteosarcoma is a malignant tumor of the bone. This cancer has the same appearance as human pediatric osteosarcoma. Osteosarcomas are tumors that arise from the abnormal production of cells that create and break down bone (called osteoblasts and osteoclasts, respectively).The long bones (arms and legs) are the most commonly affected, though bones such as the jaw, hips, or. Próxima SlideShare. of osteoid is important 1. mistaking chondroid of benign chondroblastoma for osteoid may result in diagnosis of osteosarcoma 2. rendering a acorrect diagnosis of os may depend on findng minute amt of osteoid in which well formed matrices r nt identified. m.c. in jaw bones,in women long bones & in men ribs & skull.

Osteosarcoma of the Mandible Masquerading as a Dental

OBJECTIVES: Osteosarcoma of the jaw (OSAJ) is fundamentally different in clinical practice from its peripheral counterparts. Studies are difficult to conduct due to low incidence rates. The primary aim of this study was to provide for the first time a comprehensive retrospective analysis of the treatment concepts and outcome data of OSAJ patients treated at the University Hospital Vienna and. Forteza G, Colmenero B, Lopez-Barea F. Osteogenic sarcoma of jaw: The Chaim Sheba Medical Centre experience. Oral Surg the maxilla and mandible. Oral Surg Oral Med Oral Pathol Oral Oral Med Oral Pathol Oral Radiol Endod 2001;91:445-51. Radiol Endod 1986;62:179-84. 22. High CL. Osteosarcoma of the mandible: report of a case. Oral 6 INTRODUCTION. Osteosarcoma (OSA) belongs to the most common primary malignant tumors of the bone, of which approximately 6-7% are primarily localized in the jaw bones (1-3).Approximately 5% of OSAs are thought to be secondary malignancies induced by exposure to ionizing irradiation (4-6).The reported incidence of radiation-induced OSAs is approximately 0.8% ()

Osteosarcoma ppt

Osteosarcoma of the Jaw/Craniofacial Regio

Low-grade central osteosarcoma is a rare type of osteosarcoma. In general, osteosarcomas of the jaw are high-grade lesions. Low-grade lesions are rare and include well-differentiated intramedullary osteosarcomas and parosteal osteosarcomas 2. These low-grade osteosarcomas may be mistaken for fibro-osseous neoplasms 3 Second primary malignancy (SPM) is a severe issue for cancer survivors, particularly for osteosarcoma (OS) survivors. To date, the associations between subsequent SPM and OS have been well reported. Hematogenic and solid malignancies tend to occur following OS treatment. Reportedly, 2‑[18F]‑fluoro‑2‑deoxy‑D‑glucose positron emission tomography (FDG‑PET) is mainly used in OS. Osteosarcoma is one of the most common malignant tumors in adolescent populations and the prognosis remains incompletely understand. Previous reports have demonstrated that microRNA‑124 (miR‑124) has inhibitory effects on various human malignancies and is associated with tumor progression. However, the clinical significance and potential mechanisms of miR‑124 in the progression of.

OSTEOSARCOMA / OSTEOGENIC SARCOMA • Osteosarcoma is the third most common cancer in adolescence, occurring less frequently than only lymphomas and brain tumors. • It is thought to arise from a primitive mesenchymal bone- forming cell and is characterized by production of osteoid 48 Slide 12 +13 Bone Tumors 2 - Free download as Powerpoint Presentation (.ppt / .pptx), PDF File (.pdf), Text File (.txt) or view presentation slides online. Scribd is the world's largest social reading and publishing site the abnormal production of cells that create and break down bone (called osteoblasts and osteoclasts, respectively). The long bones (arms and legs) are the most commonly affected, though bones such as the jaw, hips, or pelvis may also be affected. Osteosarcoma can also affect non-bony tissues, including the mammary glands, spleen, liver, and.

Case record. 1. Caso 2-2004: Un varón de 32-Años-de-Edad Con Dolor e Inflamación de la Mandíbula Thomas B. Dodson, Paul A. Caruso, y G. Petur Nielsen Dodson T et al. Case 2-2004: A 32-Year-Old Man with Pain and Swelling of the Jaw. The New England Journal of Medicine 2004;350:267-75 Introduction. The recent development of multidrug chemotherapy strategies for the treatment of osteosarcoma, including high-dose methotrexate (MTX), cisplatin (CDDP), adriamycin (ADR) and/or ifosfamide (IFO), in combination with orthopedic surgery has increased cure rates, which reached ~70% in patients with non-metastatic osteosarcoma

Malignant diseases of the jaws / dental coursesHead and Neck Bony TumorsBone tumors pre managementMusculoskeletal tumors

Slide 2 -. Background The problem Osteoporosis is common Over 50% of women and 30-45% of men over age 50 have osteopenia/osteoporosis White woman over age 50: 50 % lifetime risk of osteoporotic fracture, 25% risk vertebral fracture, 15% risk of hip fracture Man over age 60 has 25% risk osteoporotic fracture 70% over age 80 have osteoporosis. Half as common as osteosarcoma, rare in jaws - most are seen in adult males (mean 51 years) and affect pelvis, femur, humerus and ribs - <10% in head and neck region - swelling and loose teeth often noted Craniofacial osteosarcoma is rare (2-10% of all osteosarcomas). Most low grade fibroblastic osteosarcomas of the long bones are characterized by amplification of chromosome12q including MDM2 and CDK4 genes. This study aims to investigate the utility of MDM2 and CDK4 immunostains as well as MDM2 FISH in craniofacial osteosarcomas as a means of distinguishing them from benign fibro-osseous. presentation -pain -palpable mass-pathological # age 10-30 yrs site metaphysis of long bones -distal femur -proximal tibia -others humerus,ribs,ileum,jaw bones lung - cannonball [slideshare.net] Clinical features: Classic presentation of conventional osteosarcoma typically is progressively enlarging, painfull mass Oral Cancer Images - The Oral Cancer Foundation. This collection of photos contains both cancer and non-cancerous diseases of the oral environment which may be mistaken for malignancies. Some contain a brief patient history which may add insight to the actual diagnosis of the disease. As you review these images and their descriptions, you. Anemia & Hypercalcemia & Osteosarcoma Symptom Checker: Possible causes include Non-Hodgkin Lymphoma. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search